Spanish researchers of the Spanish Lung Cancer Group (GECP) have confirmed that cancer patients have risk to COVID-19 in a serious way than the general population. This research group conducted a GRAVID study of 447 lung cancer patients diagnosed with coronavirus. This situation occurred during the first wave in Spain in 65 hospital centers throughout Spain. This study included the most significant number of cases worldwide. The Lung Cancer Magazine has published the study.
“The results of this study are important because they confirm what we suspected, that cancer patients, especially lung cancer, are more vulnerable to this pathology. Furthermore, it is one of the world studies that has analyzed the largest number of patients ”, explains Mariano Provencio, president of the GECP.
GRAVID Study Results for Cancer Patients Riks Covid
According to this study, cancer patients are at higher risk of developing COVID-19 disease more seriously. Also, patients with advanced disease, weakened immune systems, and high LDH were at higher risk of death.
Of the total of patients analyzed:
- 78% were hospitalized;
- 2% were admitted to the ICU;
- 33% died.
Mortality was higher in patients who received corticosteroids to treat the virus at the time of hospitalization . The severity of COVID-19 was correlated with higher mortality, ICU admissions, and mechanical ventilation rates.
Most of the patients included in this registry were:
- Men (74.3%);
- Smokers or ex-smokers (85.7%);
- Non-small cell lung cancer was the most frequent type of cancer (84.5%);
- Mainly as adenocarcinoma (51.0%);
- Metastatic and inoperable disease (79.2%).
On the other hand, it should be noted that:
- Almost 60% of the patients were receiving cancer treatment, mainly chemotherapy or first-line immunotherapy.
“In this sense, it is important to emphasize that cancer therapy was not associated with an increased risk of hospitalization or death . This would mean that the administration of chemotherapy or immunotherapy in a pandemic context should not be overlooked ”, Provencio points out.
Protection of Lung Cancer Patients
With the data from this study, the GECP urges special protection of lung cancer patients against COVID-19 . “Without ceasing to administer the treatment, the risk of exposure of these patients to the virus must be minimized, adapting the health or therapeutic protocols in each case,” Provencio details.
In light of the data, the GECP also highlights that chemo and immunotherapy shouldn’t be avoided without other risk factors. This situation passes because it is not associated with worsening pathology.
They also insist that lung cancer patients should have the same access to the ICU as the general population since expectations are similar.
Lastly, the risk above factors (advanced disease and high LDH levels) should guide specialists to faster supportive treatment and probably early access to the ICU.
